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关于“晚期卵巢肿瘤患者淋巴结清扫术的随机试验”翻译学习，学习内容记录于此。 旧文重发，时间为2019-03-14
背景
BACKGROUND
系统性盆腔和主动脉旁淋巴结清扫术已被广泛用于晚期卵巢癌患者的外科治疗，但来自随机临床试验的支持证据有限。
Systematic pelvic and paraaortic lymphadenectomy has been widely used in the surgical treatment of patients with advanced ovarian cancer, although supporting evidence from randomized clinical trials has been limited.
方法
METHODS
在术中，我们将新诊断为晚期卵巢癌（国际妇产科联合会[International Federation of Gynecology and Obstetrics，FIGO]分期ⅡB期至Ⅳ期）、已接受肉眼完全切除术且术前和术中淋巴结正常的患者随机分组，分别接受或不接受淋巴结清扫术。所有研究中心在参与本试验之前必须经过手术技能方面的资格认证。主要终点是总生存期。
We intraoperatively randomly assigned patients with newly diagnosed advanced ovarian cancer (International Federation of Gynecology and Obstetrics stage IIB through IV) who had undergone macroscopically complete resection and had normal lymph nodes both before and during surgery to either undergo or not undergo lymphadenectomy. All centers had to qualify with regard to surgical skills before participation in the trial. The primary end point was overall survival.
结果
RESULTS
从2008年12月至2012年1月，共计647例患者被分配接受淋巴结清扫术（323例患者）或不接受淋巴结清扫术（324例患者），并被纳入分析。在接受淋巴结清扫术的患者中，切除的淋巴结个数中位数为57个（35个盆腔淋巴结和22个主动脉旁淋巴结）。非淋巴结清扫术组和淋巴结清扫术组的中位总生存期分别为69.2个月和65.5个月（淋巴结清扫术组死亡的风险比，1.06；95%置信区间[CI]，0.83～1.34；P=0.65），两组的中位无进展生存期为25.5个月（淋巴结清扫术组进展或死亡的风险比，1.11；95% CI，0.92～1.34；P=0.29）。淋巴结清扫术组的严重术后并发症发生率较高（例如再次开腹的发生率，12.4%vs. 6.5%[P=0.01]；术后60日内的死亡率，3.1% vs. 0.9%[P=0.049]）。
A total of 647 patients underwent randomization from December 2008 through January 2012, were assigned to undergo lymphadenectomy (323 patients) or not undergo lymphadenectomy (324), and were included in the analysis. Among patients who underwent lymphadenectomy, the median number of removed nodes was 57 (35 pelvic and 22 paraaortic nodes). The median overall survival was 69.2 months in the no-lymphadenectomy group and 65.5 months in the lymphadenectomy group (hazard ratio for death in the lymphadenectomy group, 1.06; 95% confidence interval [CI], 0.83 to 1.34; P=0.65), and median progression-free survival was 25.5 months in both groups (hazard ratio for progression or death in the lymphadenectomy group, 1.11; 95% CI, 0.92 to 1.34; P=0.29). Serious postoperative complications occurred more frequently in the lymphadenectomy group (e.g., incidence of repeat laparotomy, 12.4% vs. 6.5% [P=0.01]; mortality within 60 days after surgery, 3.1% vs. 0.9% [P=0.049]).
结论
CONCLUSIONS
在已接受腹腔内肉眼完全切除术且术前和术中淋巴结正常的晚期卵巢癌患者中，进行系统性盆腔和主动脉旁淋巴结清扫术与不进行淋巴结清扫术相比，未达到较长的总生存期或无进展生存期，并且与较高的术后并发症发生率相关（由德国研究基金会[Deutsche Forschungsgemeinschaft]和奥地利科学基金[Austrian Science Fund]资助；LION在ClinicalTrials.gov注册号为NCT00712218）。
Systematic pelvic and paraaortic lymphadenectomy in patients with advanced ovarian cancer who had undergone intraabdominal macroscopically complete resection and had normal lymph nodes both before and during surgery was not associated with longer overall or progression-free survival than no lymphadenectomy and was associated with a higher incidence of postoperative complications. (Funded by Deutsche Forschungsgemeinschaft and the Austrian Science Fund; LION ClinicalTrials.gov number, NCT00712218 .)
作者简介：
四川外国语大学成都学院翻译系英语（翻译方向）专业
重庆医科大学外国语学院英语笔译翻译硕士
英语专业八级
人事部三级、二级英语笔译资格证书持证
人事部三级英语口译资格证书持证
文思海辉技术有限公司 QQ音乐歌词翻译（全职，2014年年度优秀新人）
重庆润泽医药有限公司 医学翻译实习生（翻译、数据整理）
成都创思立信信息技术有限公司 医学翻译实习生（翻译、校对）；医学翻译、校对、导师、项目经理
曾多次为凤凰科技，解放军某高校，成都某化妆品公司提供翻译服务
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